猪重组IL-2、IL-4和IFN-γ对口蹄疫合成肽疫苗的免疫增强作用研究

doi:10.11843/j.issn.0366-6964.2015.08.015

Abstract

Abstract:

The current study was undertaken to certify the immunological adjuvant effect of recombinant IL-2，IL-4 and IFN-γ of porcine on the foot-and-mouth disease synthetic peptide vaccine.The changes of antibody and IL-4，IL-10，IL-17 and IFN-γ levels of porcines injected with synthetic peptide vaccine against foot-and-mouth disease and recombinant IL-2，IL-4 and IFN-γ of porcine，respectively.The results showed that the recombinant protein we made all had good biological activity.IL-2 and IFN-γ protein significantly increased the level of antibody against foot-and-mouth disease (P＜0.01)，while IL-4 appeared to have a suppressive effect (P＜0.01).Recombinant IL-4 significantly enhanced IL-4 and IL-10 secretions compared with that of the vaccine control group (P＜0.05).The IL-2 and IFN-γ could significantly stimulate the production of IFN-γ (P＜0.01).These results indicated that IL-2 and IFN-γ of porcine could significantly enhance the immune response against FMDV respectively.

CLC Number:

S858.285.3

TU Hao，ZHAO Xing-can，YANG Zhan-na，LI Meng-hui，XU Li-xin，YAN Ruo-feng，SONG Xiao-kai，LI Xiang-rui. Immunological Enhancement of Recombinant Porcine IL-2，IL-4 and IFN-γ on Foot-and-mouth Disease Synthetic Peptide Vaccine[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(8): 1390-1399.

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Immunological Enhancement of Recombinant Porcine IL-2，IL-4 and IFN-γ on Foot-and-mouth Disease Synthetic Peptide Vaccine

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